Larry Moran October 4, 2016 at 9:45 pm Textbook authors have been discussing this issue for decades. Most of us understand that there's a statistical mechanistic definition of entropy and we understand that the simple metaphor of disorder/randomness is not perfect.However, we have all decided that it is not our place to teach thermodynamics in a biochemistry textbook. We have also decided that the simple metaphor will suffice for getting across the basic concepts we want to teach. I've talked about this with Cox and Nelson (the authors of the Lehninger textbook) and with Don and Judy Voet (the authors of another popular textbook). Sal may not like our decision but it was a very deliberate decision to dumb down a complex subject that doesn't belong in biochemistry textbooks. It's not because we don't know any better.There are a dozen such issues in my textbook ... cases where difficult terms are deliberately over-simplified. On the other hand, there are some terms in my book that I refused to simplify even if other authors did so.